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If you have previously taken EXMD 609 you must select a topic significantly different from the one you chose for that course. Not more than one student can select any given topic. Topics in italicized red font have already been selected.

  1. Calcium imaging in live animals
  2. Genetically-encoded biosensors for intracellular molecules
  3. Chiral chromatography
  4. Purification of subcellular organelles for proteomic analysis (José Navarro)
  5. Atomic force microscopy
  6. Stimulated emission depletion (STED) microscopy (John Lin)
  7. Intravital microscopy
  8. Spinning disk confocal microscopy
  9. Multiphoton microscopy
  10. Biological applications of total internal reflection fluorescence microscopy
  11. Applications of Raman scattering microscopy in biomedical research
  12. Lensless on-chip microscopy and its biomedical applications
  13. Biomedical applications of focused ion beam microscopy
  14. Tissue imaging using mass spectrometry
  15. Nano and micro computed tomography (Adamo Donovan)
  16. Use of optical tweezers to investigate the properties of molecular motors
  17. Use of surface plasmon resonance for the study of protein-protein interactions
  18. Use of dynamic mass redistribution to evaluate intracellular signaling responses
  19. Generation of genetically engineered animals for food: Methods, controversies and justifications
  20. Recent progress in in vivo genome editing: Methods, comparative discussion and implications on health research
  21. Chromatin immunoprecipitation (ChIP) (Ildi Troka)
  22. Tools to investigate miRNA expression and function
  23. Recently-developed methods for the in vitro transfection of cells (excluding calcium phosphate & standard lipofection)
  24. Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase (DamID)
  25. Chromosome conformation capture methodology
  26. The use of transposons to study gene functions
  27. Exome sequencing
  28. Single-cell transcriptomics
  29. In situ sequencing: sequencing genetic material directly from intact tissues
  30. Probes for real-time detection and perturbation of cellular signaling (Aaron Cho)
  31. Bioinformatic methods used to understand gene expression regulation in systems biology approaches 
  32. Genome-wide association studies
  33. Identification of protein interactions using phototrapping and photocrosslinking
  34. Use of tandem affinity purification (TAP) for the identification of protein interactions
  35. Determination of the biosynthetic pathways of small peptides
  36. Methods used to study the internalization and fate of cell membrane receptors (Alexander Makarkov)
  37. Use of NMR in protein characterization
  38. Characterization of proteins by X-ray crystallography
  39. Investigation of protein dynamics using time-resolved X-ray crystallography
  40. Investigation of conformational changes in proteins using ultrafast X-ray free-electron lasers
  41. Determination of protein structure using single-particle cryo-electron microscopy
  42. High throughput methods to identify receptor antagonists (Natalie Jones)
  43. Drug development using combinatorial chemistry
  44. Carbon nanotubes and their potential use for drug delivery
  45. New methods for drug delivery and targeting (excluding carbon nanotubes) (Ka Yee Lok)
  46. Gene therapy (Haya Aldossary)
  47. DNA vaccines
  48. Dendritic cell vaccines (Zander Willms)
  49. Oncolytic viruses in cancer therapy (Rehka Raveendrakumar)
  50. Use of adoptive cell transfer in biomedical research (Emma Fowler)
  51. Biomedical applications of 3D printing (Sonali Uttam)
  52. Scaffolds and cells for tissue engineering (Mellissa Gaudet)
  53. Intracellular probes to measure oxidative stress
  54. Methods used to assess angiogenesis
  55. Applications of ribozymes in medical research
  56. Biomedical applications of quantum dots
  57. Biomedical applications of magnetic nanoparticles
  58. Mapping of neural circuits (Matthew Barnett)
  59. Experimental treatment of disease by transplantation of neuronal cells
  60. Optogenetics and its applications (Abubakr Mossa)
  61. Living cell microarrays
  62. Production and applications of organoids (Joyce Jang)
  63. "Disease in a dish" using induced pluripotent stem cells
  64. Single cell mass cytometry
  65. Use of gene drives to target mosquito-borne diseases: methodology, current progress and ethical issues
  66. Epitranscriptome analysis
  67. Biomedical and therapeutic applications of aptamers
  68. Biomedical and therapeutic applications of focused ultrasound
  69. Targeting RNA using CRISPR
  70. In silico approaches to drug development