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You must choose one of the topics below for your seminar/term paper. If you have previously taken EXMD 610 your topic must differ significantly from the one you chose for that course. Not more than one student can select any given topic. Topics in italicized red font have already been selected.

  1. Calcium imaging in live animals (Zhaoyu Wang)
  2. Genetically-encoded biosensors for intracellular molecules
  3. Chiral chromatography
  4. Purification of subcellular organelles for proteomic analysis
  5. Atomic force microscopy
  6. Stimulated emission depletion (STED) microscopy
  7. Intravital microscopy
  8. Spinning disk confocal microscopy
  9. Multiphoton microscopy
  10. Biological applications of total internal reflection fluorescence microscopy
  11. Applications of Raman scattering microscopy in biomedical research
  12. Lensless on-chip microscopy and its biomedical applications
  13. Biomedical applications of focused ion beam microscopy
  14. Tissue imaging using mass spectrometry
  15. Nano and micro computed tomography
  16. Use of optical tweezers to investigate the properties of molecular motors
  17. Use of surface plasmon resonance for the study of protein-protein interactions
  18. Use of dynamic mass redistribution to evaluate intracellular signaling responses
  19. Generation of genetically engineered animals for food: Methods, controversies and justifications (Timothy Liao)
  20. Recent progress in in vivo genome editing: Methods, comparative discussion and implications on health research
  21. Chromatin immunoprecipitation (ChIP) (Sathyen Prabhu)
  22. Tools to investigate miRNA expression and function
  23. Recently-developed methods for the in vitro transfection of cells¬†(excluding calcium phosphate & standard lipofection)
  24. Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase (DamID)
  25. Chromosome conformation capture methodology
  26. The use of transposons to study gene functions (Jennifer Gantchev)
  27. Exome sequencing (Marion Lacroix)
  28. Single-cell transcriptomics
  29. In situ sequencing: sequencing genetic material directly from intact tissues
  30. Probes for real-time detection and perturbation of cellular signaling
  31. Bioinformatic methods used to understand gene expression regulation in systems biology approaches
  32. Genome-wide association studies (Rebecca Robertson)
  33. Identification of protein interactions using phototrapping and photocrosslinking
  34. Use of tandem affinity purification (TAP) for the identification of protein interactions
  35. Determination of the biosynthetic pathways of small peptides
  36. Methods used to study the internalization and fate of cell membrane receptors (Henry Yu)
  37. Use of NMR in protein characterization
  38. Characterization of proteins by X-ray crystallography
  39. Investigation of protein dynamics using time-resolved X-ray crystallography
  40. Investigation of conformational changes in proteins using ultrafast X-ray free-electron lasers
  41. Determination of protein structure using single-particle cryo-electron microscopy
  42. High throughput methods to identify receptor antagonists
  43. Drug development using combinatorial chemistry
  44. Carbon nanotubes and their potential use for drug delivery (Kaleela Kadir)
  45. New methods for drug delivery and targeting (excluding carbon nanotubes)
  46. Gene therapy (Niusha Khazaei)
  47. DNA vaccines (Robert Dziarmaga)
  48. Dendritic cell vaccines (Jamilah Abusarah)
  49. Oncolytic viruses in cancer therapy (Qian Li)
  50. Use of adoptive cell transfer in biomedical research
  51. Biomedical applications of 3D printing
  52. Scaffolds and cells for tissue engineering (Neelakshi Pandey)
  53. Intracellular probes to measure oxidative stress (Dana Abou Samhadaneh)
  54. Methods used to assess angiogenesis
  55. Applications of ribozymes in medical research
  56. Biomedical applications of quantum dots
  57. Biomedical applications of magnetic nanoparticles
  58. Mapping of neural circuits (Jeffery Wang)
  59. Experimental treatment of disease by transplantation of neuronal cells
  60. Optogenetics and its applications
  61. Living cell microarrays
  62. Production and applications of organoids (Irina Perlitch)
  63. "Disease in a dish" using induced pluripotent stem cells (Sibat Anam)
  64. Organs on chips to model human diseases (Ali Reyes)
  65. Single cell mass cytometry (Sabrina Bartolucci)
  66. Use of gene drives to target mosquito-borne diseases: methodology, current progress and ethical issues (Danielle Kasis Akal)
  67. Epitranscriptome analysis
  68. Biomedical and therapeutic applications of aptamers (Wendy Zhao)
  69. Biomedical and therapeutic applications of focused ultrasound
  70. Targeting RNA using CRISPR (Yue Liang)
  71. In silico approaches to drug development